| Identification | Back Directory | [Name]
M40 | [CAS]
143896-17-7 | [Synonyms]
M40
MGC16435
MGC117247
M40?, >98%
OK/SW-cl.56
GWTLNSAGYLLGPPPALALA-NH2
Tubulin, GST tagged human
M40,GWTLNSAGYLLGPPPALALA, >98%
GALANIN FRAGMENT 1-13-PRO-PRO-ALA-LEU- &
GALANIN (1-13) - PRO2(ALA-LEU)2-ALA AMIDE
GALANIN (1-13)-PRO-PRO-(ALA-LEU)2-ALA, AMIDE
Galanin (1-13)-Pro-Pro-(Ala-Leu-)2Ala aMide
M40
galanin fragment 1-13-pro-pro-ala-*leu-ala-leu-al
GALANIN FRAGMENT 1-13-PRO-PRO-ALA-LEU-ALA-LEU-ALA-AMIDE
GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-PRO-PRO-PRO-ALA-LEU-ALA-LEU-ALA-NH2
H-GLY-TRP-THR-LEU-ASN-SER-ALA-GYR-TYR-LEU-LEU-GLY-PRO-PRO-PRO-ALA-LEU-ALA-LEU-ALA-NH2
H-GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-PRO-PRO-PRO-ALA-LEU-ALA-LEU-ALA-NH2
REF DUPL: H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2
L-Alaninamide, glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-prolyl-L-prolyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl- | [Molecular Formula]
C94H145N23O24 | [MDL Number]
MFCD00671424 | [MOL File]
143896-17-7.mol | [Molecular Weight]
1981.3 |
| Hazard Information | Back Directory | [Uses]
GST tagged tubulin has been used in Western blotting and in mass spec as a control. | [Biological Activity]
Tubulin-β 1 (TUBB1) interaction with microtubule-associated proteins (MAPs) such as tau is fundamental for microtubule structure and function. It has a role in the formation of the cytoskeleton. Studies revealed th at TUBB1 is the target of various antitubulin agents used in the treatment of cancer. Subsequent studies have also concluded th at TUBB1 mutations in clinical samples are rareand unlikely to contribute to drug resistance. | [in vivo]
M40 (0.1-1 nmol, intracisternal injection, single dose) blocks selectively the central cardiovascular responses induced by galanin-(1–15) in Sprague-Dawley rats models, according to the recognization of galanin receptor in N-terminus[1].
M40 (2-8 nmol, intraventricular or intrahippocampal, single dose) exhibits antagonist efficacy against galanin on memory tasks in sprague-dawley rats models, exhibits potency in alleviating the cognitive deficits associated with Alzheimer's disease[2]. | Animal Model: | Vasopressor and tachycardia induced by galanin in Sprague-Dawley rats[1] | | Dosage: | 0.1-1 nmol | | Administration: | Intracisternal injection, single dose | | Result: | Blocked the feeding effects of galanin in the hypothalamus and amygdala.
Reduced vasopressor response and heart rate induced by galanin-(1-15), but not those effects induced by galanin-(1-29). |
| Animal Model: | Memory impairment induced by galanin in rats model[2] | | Dosage: | 2-8 nmol | | Administration: | intraventricular or intrahippocampal, single dose | | Result: | Blocked the impairment in choice accuracy. |
| [storage]
Store at -20°C |
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