| Identification | Back Directory | [Name]
Morphinan-3-amine, 17-methyl-, (9α,13α,14α)- (9CI) | [CAS]
143899-90-5 | [Synonyms]
Morphinan-3-amine, 17-methyl-, (9α,13α,14α)- (9CI) | [Molecular Formula]
C17H24N2 | [MOL File]
143899-90-5.mol | [Molecular Weight]
256.39 |
| Hazard Information | Back Directory | [Uses]
Antidepressant agent 9 (Compound 24) is an orally active and BBB-penatrable NMDAR and SERT inhibitor with IC50 values of 3.50 μM and 1044 nM, respectively. Antidepressant agent 9 has good metabolic stability and plasma exposure. Antidepressant agent 9 can exert antidepressant-like activity in the mouse forced swim test[1]. | [References]
[1] Ji J, et al. D-morphinan analogs with favorable pharmacokinetic profiles as dual-acting antidepressants. Eur J Med Chem. 2025 Apr 5;287:117349. DOI:10.1016/j.ejmech.2025.117349 |
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