| Hazard Information | Back Directory | [Description]
VU0463841 is a negative allosteric modulators of mGlu5. | [Uses]
VU0463841 is a potent, selective and brain-penetrant mGlu5 negative allosteric modulator (NAM) with an IC50 of 13 nM. VU0463841 is ineffective against mGlu1-4 and mGlu7-8. VU0463841 has the potential for the Cocaine addiction research[1]. | [IC 50]
mGlu5 Receptor: 13 nM (IC50) | [References]
[1] Russell J Amato, et al. Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction. ACS Chem Neurosci. 2013 Aug 21;4(8):1217-28. DOI:10.1021/cn400070k |
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