| Identification | Back Directory | [Name]
BRD73954 | [CAS]
1440209-96-0 | [Synonyms]
CS-1777
BRD73954
BRD-73954;BRD 73954
N1-hydroxy-N3-phenethylisophthalamide
N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide
1,3-Benzenedicarboxamide, N1-hydroxy-N3-(2-phenylethyl)-
BRD73954, 1-N-hydroxy-3-N-(2-phenylethyl)benzene-1,3-dicarboxamide
N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide BRD73954 | [Molecular Formula]
C16H16N2O3 | [MDL Number]
MFCD26383435 | [MOL File]
1440209-96-0.mol | [Molecular Weight]
284.31 |
| Chemical Properties | Back Directory | [Melting point ]
172-175oC | [density ]
1.245±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
8.56±0.10(Predicted) | [color ]
Off-White | [InChI]
1S/C16H16N2O3/c19-15(17-10-9-12-5-2-1-3-6-12)13-7-4-8-14(11-13)16(20)18-21/h1-8,11,21H,9-10H2,(H,17,19)(H,18,20) | [InChIKey]
FIHKWEQJEDRIFS-UHFFFAOYSA-N | [SMILES]
ONC(C1=CC(C(NCCC2=CC=CC=C2)=O)=CC=C1)=O |
| Hazard Information | Back Directory | [Description]
BRD73954 is a dual inhibitor of histone deacetylase 6 (HDAC6) and HDAC8 (IC50s = 36 and 120 nM, respectively). It is selective for HDAC6 and -8 over HDAC1-5, -7, and -9 (IC50s = 12, 9, 23, >33, >33, 13, and >33 μM, respectively). BRD73954 (10 μM) increases acetylation of α-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, -2, and -3, in HeLa cells. | [Uses]
BRD73954 is a small molecule inhibitor which has the ability to inhibit HDAC6 and HDAC8. Affects cell adhesion and mobility in cells. | [IC 50]
HDAC6: 0.036 μM (IC50); HDAC8: 0.12 μM (IC50); HDAC2: 9 μM (IC50); HDAC1: 12 μM (IC50); HDAC3: 23 μM (IC50) | [storage]
Store at +4°C | [References]
[1]. olson de, wagner ff, kaya t, et al. discovery of the first histone deacetylase 6/8 dual inhibitors. j med chem, 2013, 56(11): 4816-4820. |
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| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
|