ChemicalBook--->CAS DataBase List--->144035-83-6

144035-83-6

144035-83-6 Structure

144035-83-6 Structure
IdentificationBack Directory
[Name]

Piclamilast
[CAS]

144035-83-6
[Synonyms]

RP 73401
RPR 73401
piclamilas
Piclamilast
N-(3,5-Dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide
3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamide
3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide
3-(Cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide
Benzamide,3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-
[Molecular Formula]

C18H18Cl2N2O3
[MOL File]

144035-83-6.mol
[Molecular Weight]

381.25
Chemical PropertiesBack Directory
[Boiling point ]

447.8±45.0 °C(Predicted)
[density ]

1.370
[storage temp. ]

2-8°C
[solubility ]

DMSO: soluble20mg/mL, clear
[form ]

powder
[pka]

10.10±0.70(Predicted)
[color ]

white to beige
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

Piclamilast is a potent and selective phosphodiesterase-4 (PDE4) inhibitor. Piclamilast may offer therapeutic strategies in respiratory diseases, including asthma and chronic obstructive pulmonary disease. Piclamilast may also provide a treatment option for pre-term infants with bronchopulmonary dysplasia (BPD).
[Definition]

ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 3-(cyclopentyloxy)-4-methoxybenzoic acid with the primary amino group of 3,5-dichloropyridin-4-amine.
[storage]

Store at RT
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