| Identification | Back Directory | [Name]
1,6-Naphthyridin-4(1H)-one, 5-[[3-fluoro-4-[(7-methoxy-4-quinolinyl)oxy]phenyl]amino]-3-(4-fluorophenyl)- | [CAS]
1446324-05-5 | [Synonyms]
c-Met-IN-11
1,6-Naphthyridin-4(1H)-one, 5-[[3-fluoro-4-[(7-methoxy-4-quinolinyl)oxy]phenyl]amino]-3-(4-fluorophenyl)- | [Molecular Formula]
C30H20F2N4O3 | [MOL File]
1446324-05-5.mol | [Molecular Weight]
522.5 |
| Hazard Information | Back Directory | [Uses]
c-Met-IN-11 (compound 3) is a potent c-MET and VEGFR-2 inhibitor, with IC50 values of 41.4 and 71.1 nM, respectively[1]. | [IC 50]
VEGFR-2: 71.1 nM (IC50) | [References]
[1] Xu H, et al. Discovery of N-substituted-3-phenyl-1,6-naphthyridinone derivatives bearing quinoline moiety as selective type II c-Met kinase inhibitors against VEGFR-2. Bioorg Med Chem. 2020 Jun 15;28(12):115555. DOI:10.1016/j.bmc.2020.115555 |
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