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Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses[1][2][3][4][5]. | [Definition]
ChEBI:1,2-distearoyl-sn-glycero-3-phosphoserine is a 3-sn-phosphatidyl L-serine in which the phosphatidyl acyl group at both positions 1 and 2 is stearoyl. It has a role as a mouse metabolite. It is functionally related to an octadecanoic acid. | [in vivo]
Phosphatidylserine, after forming liposomes with PC and cholesterol in a molar ratio of 30:30:40 (0.5 mg liposome; single dose; s.c.), can inhibit immune responses in vivo by binding to and enhancing the activation of the Phosphatidylserine receptor[2]. | Animal Model: | BALB/cAnN and C57BL/6 male mice[2]. | | Dosage: | Phosphatidylserine (PS) liposomes (0.5 mg of total lipid, PS-containing liposomes consisted of 30:30:40 molar ratio PS to PC to cholesterol) | | Administration: | Subcutaneous injection (s.c.); single dose | | Result: | Inhibited responses to Ags as determined by decreased draining lymph node tissue mass, with reduced numbers of total leukocytes and Ag-specific CD4+ T cells. |
| [storage]
Store at -20°C | [References]
[1] Kay JG, et al. Phosphatidylserine-mediated cellular signaling. Adv Exp Med Biol. 2013;991:177-93. DOI:10.1007/978-94-007-6331-9_10
[2] Hoffmann PR, et al. Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J Immunol. 2005 Feb 1;174(3):1393-404. DOI:10.4049/jimmunol.174.3.1393
[3] Kim HY, et al. Phosphatidylserine in the brain: metabolism and function. Prog Lipid Res. 2014 Oct;56:1-18. DOI:10.1016/j.plipres.2014.06.002
[4] Scott-Hewitt N, et al. Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia. EMBO J. 2020 Aug 17;39(16):e105380. DOI:10.15252/embj.2020105380
[5] Huang BX, et al. Phosphatidylserine is a critical modulator for Akt activation. J Cell Biol. 2011 Mar 21;192(6):979-92. |
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