| Identification | Back Directory | [Name]
L-Tryptophan, L-cysteinyl-L-threonyl-L-cysteinyl-L-lysyl-L-α-aspartyl-L-methionyl-L-threonyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-leucyl-L-tyrosyl-L-phenylalanyl-L-cysteinyl-L-histidyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-, cyclic (1→15),(3→11)-bis(disulfide) | [CAS]
1446991-36-1 | [Synonyms]
L-Tryptophan, L-cysteinyl-L-threonyl-L-cysteinyl-L-lysyl-L-α-aspartyl-L-methionyl-L-threonyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-leucyl-L-tyrosyl-L-phenylalanyl-L-cysteinyl-L-histidyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-, cyclic (1→15),(3→11)-bis(disulfide) | [Molecular Formula]
C112H163N27O34S5 | [MOL File]
1446991-36-1.mol | [Molecular Weight]
2591.99 |
| Chemical Properties | Back Directory | [Boiling point ]
2560.8±65.0 °C(predicted) | [density ]
1.292±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [Sequence]
Cys-Thr-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Ile-Ile-Trp (disulfide bridge: Cys1-Cys15, Cys3-Cys11) |
| Hazard Information | Back Directory | [Uses]
Sarafotoxin S6d (STX-b) is a polypeptide toxin isolated from the venom of the Israeli sand boa constrictor. Sarafotoxin S6d induces multiple electrocardiogram (ECG) changes including myocardial ischemia and hyperkalemia. Sarafotoxin S6d induces strong extracellular calcium-dependent vasoconstriction in rat aorta and exhibits positive inotropic effects in rat atria. Sarafotoxin S6d can be used in the study of cardiovascular diseases[1]. | [in vivo]
Sarafotoxin S6d (0.3, 1.0, 3.0 and 5.0 nmol/kg; i.v.) can produce a constant pressure effect and a short pulse pressure increase at 0.3-3.0 nmol/kg. However, at 5.0 nmol/kg, Sarafotoxin S6d can cause a rapid drop in blood pressure, heart rate, and breathing rate after an initial increase, leading to the deaths of most mice within 10 minutes[1].
Sarafotoxin S6d (5.0 nmol/kg; i.v.) increases K+ levels by 159% significantly. Additionally, plasma enzymes (LDH, CPK), IP, and glucose levels are also significantly elevated. LDH increases by 60%, CPK by 91%, IP by 137%, and glucose by 80%[1].
| [References]
[1] Lin W W, et al. Cardiovascular effects of two disulfide analogues of sarafotoxin S6b[J]. Toxicon, 1990, 28(8): 911-923. DOI:10.1016/0041-0101(90)90021-x |
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