| Identification | Back Directory | [Name]
tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate | [CAS]
1448189-98-7 | [Synonyms]
184607
(S,R,S)-AHPC-Boc
L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
tert-butyl ((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate | [Molecular Formula]
C27H38N4O5S | [MDL Number]
MFCD31692982 | [MOL File]
1448189-98-7.mol | [Molecular Weight]
530.68 |
| Chemical Properties | Back Directory | [Melting point ]
82-83 °C | [Boiling point ]
755.7±60.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
-20°C, stored under nitrogen | [form ]
Solid | [pka]
11.57±0.46(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Description]
(S,R,S)-AHPC-BOC is a ligand used to recruit the von Hippel-Lindau protein. | [Uses]
(S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Boc is used in PROTAC technology[1]. | [IC 50]
VHL | [References]
[1] Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015;10(8):1770‐1777. DOI:10.1021/acschembio.5b00216 |
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