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TP receptor antagonist-2 (example 7n) is a thromboxane A2 receptor (TP receptor) antagonist, with IC50 values of 5.64 and 5.27 μM for TPα and TPβ, respectively. TP receptor antagonist-2 inhibits platelet aggregation[1]. | [References]
[1] Bambi-Nyanguile SM, et al. Synthesis and pharmacological evaluation of 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as novel thromboxane A? receptor antagonists. Eur J Med Chem. 2013 Jul;65:32-40. DOI:10.1016/j.ejmech.2013.04.033 |
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