| Identification | Back Directory | [Name]
Dodecaborate(2-),1,2,3,4,5,6,7,8,9,10,11-undecahydro-12-mercapto-, sodium (1:2) | [CAS]
144885-51-8 | [Synonyms]
Sodium mercaptododecaborate, N-BSH
Dodecaborate(2-),1,2,3,4,5,6,7,8,9,10,11-undecahydro-12-mercapto-, sodium (1:2) | [Molecular Formula]
B12HNaS+ | [MOL File]
144885-51-8.mol | [Molecular Weight]
185.78 |
| Hazard Information | Back Directory | [Uses]
Borocaptate sodium is a boron-containing compound that can be used as a therapeutic agent in boron neutron capture therapy (BNCT), exhibiting anticancer activity[1][2]. | [in vivo]
Borocaptate sodium (55 mg/kg, i.v., single dose) selectively targets intracranial tumors in dogs and inhibits their growth[2]. | Animal Model: | Spontaneous intracranial tumor-bearing dogs (primarily gliomas, mixed breed dogs, typically between 5-10 years old, weight 20-30 kg)[2] | | Dosage: | 55 mg/kg | | Administration: | Intravenous injection (i.v.), single dose | | Result: | Resulted in boron concentrations of 35.9 μg/g in the tumor at 2 hours, 22.5 μg/g at 6 hours, and 7.0 μg/g at 12 hours. The boron concentration in the tumor was higher than that in normal brain tissue, with a favorable tumor-to-brain ratio. |
| [References]
[1] Bendel P, et al. Optimal detection of the neutron capture therapy agent borocaptate sodium (BSH): A comparison between and NMR[J]. Medical Physics, 2001, 28(2): 178-183. DOI:10.1118/1.1339227
[2] Kraft SL, et al. Borocaptate sodium: a potential boron delivery compound for boron neutron capture therapy evaluated in dogs with spontaneous intracranial tumors. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11973-7. DOI:10.1073/pnas.89.24.11973
[3] Yoshida F, et al. Enhancement of sodium borocaptate (BSH) uptake by tumor cells induced by glutathione depletion and its radiobiological effect. Cancer Lett. 2004 Nov 8;215(1):61-7. DOI:10.1016/j.canlet.2004.06.023
[4] Kokai-Kun J F, et al. Lysostaphin as a treatment for systemic Staphylococcus aureus infection in a mouse model[J]. Journal of antimicrobial chemotherapy, 2007, 60(5): 1051-1059. DOI:10.1093/jac/dkm347 |
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