| Identification | Back Directory | [Name]
N-(8Z-Heptadecen-1-yl)-O-(3-pyridylmethyl)carbamate | [CAS]
1450603-63-0 | [Synonyms]
N-(8Z-Heptadecen-1-yl)-O-(3-pyridylmethyl)carbamate
3-pyridinylmethylesterN-(8Z)-8-heptadecen-1-yl-carbamicacid
Carbamic acid, N-(8Z)-8-heptadecen-1-yl-, 3-pyridinylmethyl ester | [Molecular Formula]
C24H40N2O2 | [MOL File]
1450603-63-0.mol | [Molecular Weight]
388.59 |
| Chemical Properties | Back Directory | [Boiling point ]
527.9±43.0 °C(Predicted) | [density ]
0.966±0.06 g/cm3(Predicted) | [solubility ]
DMF: 50 mg/mL; DMSO: 30 mg/mL; Ethanol: 50 mg/mL; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/mL | [form ]
A crystalline solid | [pka]
12.34±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
N-(8Z-Heptadecen-1-yl)-O-(3-pyridylmethyl)carbamate is a synthetic analog of the long-chain fatty acid amides (macamides or macaenes) isolated from the maca (L. meyenii) plant, which are structurally related to cannabinoids. Nineteen macamides have currently been identified and many are recognized as potent inhibitors of fatty acid amide hydrolase (FAAH) and demonstrate selective antiproliferative activity against diverse cancer cell lines. N-(8Z-Heptadecen-1-yl)-O-(3-pyridylmethyl)carbamate irreversibly inhibits FAAH with an IC50 value of 0.153 μM. | [Uses]
FAAH inhibitor 2 (Compound 17b) is an irreversible fatty acid amide hydrolase (FAAH) inhibitor, with an IC50 of 0.153 μM[1]. | [References]
[1] Wu H, et al. Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition. Bioorg Med Chem. 2013 Sep 1;21(17):5188-97. DOI:10.1016/j.bmc.2013.06.034 |
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