| Identification | Back Directory | [Name]
SBI-425 | [CAS]
1451272-71-1 | [Synonyms]
SBI-425
3-Pyridinecarboxamide, 5-[[(5-chloro-2-methoxyphenyl)sulfonyl]amino]- | [Molecular Formula]
C13H12ClN3O4S | [MDL Number]
MFCD31652984 | [MOL File]
1451272-71-1.mol | [Molecular Weight]
341.77 |
| Chemical Properties | Back Directory | [Boiling point ]
582.1±60.0 °C(Predicted) | [density ]
1.509±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble | [form ]
A solid | [pka]
6.21±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
SBI-425 is a potent, selective and orally bioavailable compound that robustly inhibits tissue-nonspecific alkaline phosphatase (TNAP) in vivo. | [Uses]
SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival[1][2]. | [in vivo]
1.19 Mouse PK parameters for SBI-425[1]| Compds | SBI-425 | | Clp (mL/min/kg) | 5.14 | | Vd (L/kg) | 1.03 | | Cmax (μg/mL) | 178 | | AUC (μg*hr/mL) | 848 | | t1/2 (hr) | 2.3 | | %F | 58 | |
| [storage]
Store at -20°C | [References]
[1] Pinkerton AB, et al. Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34. DOI:10.1016/j.bmcl.2017.11.024
[2] Sheen CR, et al. Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification. J Bone Miner Res. 2015 May;30(5):824-36. DOI:10.1002/jbmr.2420
[3] Brichacek AL, et al. Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis. Sci Rep. 2019 Dec 11;9(1):18788. DOI:10.1038/s41598-019-55154-2 |
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