| Identification | Back Directory | [Name]
leustroducsin B | [CAS]
145142-82-1 | [Synonyms]
LSN B
leustroducsin B
Octanoic acid, 6-methyl-, (1S,3R)-3-[(1Z,3Z,5R,7R,8R,9E)-8-(2-aminoethyl)-10-[(2S,3S)-3-ethyl-3,6-dihydro-6-oxo-2H-pyran-2-yl]-5,8-dihydroxy-7-(phosphonooxy)-1,3,9-decatrien-1-yl]cyclohexyl ester, (6S)- | [Molecular Formula]
C34H56NO10P | [MDL Number]
MFCD00924317 | [MOL File]
145142-82-1.mol | [Molecular Weight]
669.78 |
| Hazard Information | Back Directory | [Description]
Leustroducsin B is a novel colony-stimulating factor (CSF) inducer isolated from Streptomyces platensis SANK 60191. | [Uses]
Leustroducsin B is a colony-stimulating factor (CSF) inducer. Leustroducsin B induces CSF production in bone marrow stromal cells[1]. | [in vivo]
Leustroducsin B (0.1-0.3 mg/kg; ip; once daily; for three to six days) induces thrombocytosis in mice[1]. | Animal Model: | Pathogen-free C57BL/6 male mice (Seven-week-old)[1] | | Dosage: | 0.1 mg/kg; 0.3 mg/kg | | Administration: | ip; once daily; for three to six days | | Result: | Induced thrombocytosis in mice.
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| [References]
[1] T Kohama, et al. Leustroduscin B, a new cytokine inducer derived from an actinomycetes, induces thrombocytosis in mice. J Antibiot (Tokyo). 1996 Jan;49(1):91-4. DOI:10.7164/antibiotics.49.91 |
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