| Identification | Back Directory | [Name]
tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate | [CAS]
145166-06-9 | [Synonyms]
-2-hydroxycyclohexyl)
2S)-2-hydroxycyclohexyl]-
1S,S-Boc-2-aMinocyclohexanol
(1S,2S)-N-Boc-2-aminocyclohexanol
(1S,2S)-trans-N-Boc-2-Aminocyclohexanol
(1S,2S)-N-Boc-2-aminocyclohexanol,99%e.e.
ert-Butyl((1S,2S)-2-hydroxycyclohexyl)carbamate
tert-butyl (1S,2S)-2-hydroxycyclohexylcarbamate
tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate
tert-butyl N-[(1S,2S)-2-hydroxycyclohexyl]carbamate
tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate USP/EP/BP
CarbaMic acid, N-[(1S,2S)-2-hydroxycyclohexyl]-, 1,1-diMethylethyl ester
Carbamic acid, [(1S,2S)-2-hydroxycyclohexyl]-, 1,1-dimethylethyl ester (9CI) | [Molecular Formula]
C11H21NO3 | [MDL Number]
MFCD11042330 | [MOL File]
145166-06-9.mol | [Molecular Weight]
215.29 |
| Chemical Properties | Back Directory | [Boiling point ]
337.7±31.0 °C(Predicted) | [density ]
1.06±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [form ]
solid | [pka]
12.11±0.40(Predicted) | [Appearance]
White to off-white Solid | [BRN ]
5810950 | [InChI]
InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-8-6-4-5-7-9(8)13/h8-9,13H,4-7H2,1-3H3,(H,12,14)/t8-,9-/m0/s1 | [InChIKey]
XVROWZPERFUOCE-IUCAKERBSA-N | [SMILES]
C(OC(C)(C)C)(=O)N[C@H]1CCCC[C@@H]1O |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of trans-N-Boc-cyclohexylamino alcohols from the compounds (CAS: 764659-69-0): the product of part A (8.0 g, 26.2 mmol) was dissolved in a solvent mixture of cyclohexene (100 mL) and ethanol (150 mL), and palladium/carbon catalyst (2.0 g) was added. The reaction mixture was heated to reflux for 6 h. Upon completion of the reaction, the catalyst was removed by filtration through a Celite pad. The filtrate was concentrated to afford tert-butyl (1S,2S)-2-hydroxy-cyclohexyl-carbamate (5.7 g, 100% yield) as a white solid. Mass spectral analysis showed M/Z 216.2 ([M + H]+). | [References]
[1] Patent: WO2004/83174, 2004, A2. Location in patent: Page 172
[2] Patent: WO2005/87731, 2005, A1. Location in patent: Page/Page column 321
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 16, p. 4419 - 4427
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 1, p. 119 - 132 |
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