| Identification | Back Directory | [Name]
4-Hydroxy Xylazine | [CAS]
145356-32-7 | [Synonyms]
4-Hydroxy Xylazine
Xylazine Impurity 10
4-[(5,6-Dihydro-4H-1,3-thiazin-2-yl)aMino]-3,5-diMethylphenol
Phenol, 4-[(5,6-dihydro-4H-1,3-thiazin-2-yl)amino]-3,5-dimethyl- | [Molecular Formula]
C12H16N2OS | [MOL File]
145356-32-7.mol | [Molecular Weight]
236.33 |
| Chemical Properties | Back Directory | [Melting point ]
250-252°C (dec.) | [Boiling point ]
391.7±52.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer, Under Inert Atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
10.85±0.36(Predicted) | [color ]
Off-White to Brown |
| Hazard Information | Back Directory | [Description]
4-hydroxy Xylazine is a metabolite of xylazine (Item Nos. 14113 | 22641). Xylazine is an agonist of α2-adrenergic receptors used for sedation, anesthesia, and analgesia in non-human mammals. 4-hydroxy Xylazine has been used as a marker for xylazine doping in MS analysis of equine urine. | [Chemical Properties]
Off-White to Tan Solid | [Uses]
A major metabolite | [Uses]
A major metabolite of Xylazine (X748000). | [storage]
Store at -20°C | [References]
[1] A E MUTLIB. Characterization of metabolites of xylazine produced in vivo and in vitro by LC/MS/MS and by GC/MS.[J]. Drug Metabolism and Disposition, 1992, 20 6: 840-848.
[2] M.-H. SPYRIDAKI . Determination of xylazine and its metabolites by GC–MS in equine urine for doping analysis[J]. Journal of pharmaceutical and biomedical analysis, 2004, 35 1: Pages 107-116. DOI: 10.1016/j.jpba.2003.12.007
[3] W. H. KWOK. Screening of over 100 drugs in horse urine using automated on-line solid-phase extraction coupled to liquid chromatography-high resolution mass spectrometry for doping control.[J]. Journal of Chromatography A, 2017, 44 1: 89-101. DOI: 10.1016/j.chroma.2017.02.020
[4] RAIMO VIRTANEN . Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist[J]. European journal of pharmacology, 1988, 150 1: Pages 9-14. DOI: 10.1016/0014-2999(88)90744-3
[5] CLAIRE A RICHARDSON Paul A F. Anaesthesia and post-operative analgesia following experimental surgery in laboratory rodents: are we making progress?[J]. Atla-Alternatives To Laboratory Animals, 2005, 33 2: 119-127. DOI: 10.1177/026119290503300207
[6] DVM A V, DVSC. Alpha-2 Agonists as Pain Therapy in Horses[J]. Veterinary Clinics of North America-Equine Practice, 2010, 26 3: Pages 515-532. DOI: 10.1016/j.cveq.2010.07.003 |
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