| Identification | Back Directory | [Name]
SH5-07 | [CAS]
1456632-41-9 | [Synonyms]
SH5-07
SH5-07 (SH-5-07)
Benzamide, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-N-hydroxy- | [Molecular Formula]
C29H28F5N3O5S | [MDL Number]
MFCD30718177 | [MOL File]
1456632-41-9.mol | [Molecular Weight]
625.61 |
| Chemical Properties | Back Directory | [density ]
1.437±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (79.92 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
9.03±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SH5-?07 is a STAT3-inhibitor blocking the activation of signal transduction and subsequent activation of transcription 3 in chronic myeloid leukemia cell lines. | [in vivo]
Tail vein injection or oral gavage delivery of SH5-07 or SH4-54 inhibits growth of 90-150 mm3 established subcutaneous mouse xenografts of human glioma (U251MG) and breast (MDA-MB-231) tumors that harbor aberrantly-active Stat3, associated with decreased c-Myc, Mcl-1 and Cyclin D1 expression. No significant changes in body weights, blood cell counts, or the gross anatomy of organs, or obvious signs of toxicity are observed[1]. | [IC 50]
STAT3: 3.9 μM (IC50) |
|
| Company Name: |
Twochem Co.Ltd.
|
| Telephone: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|