| Identification | Back Directory | [Name]
CETRORELIX | [CAS]
145672-81-7 | [Synonyms]
Ns 75a
D 20761
Cetrotid
Ovurelix
Sb 075 acetate
Cetrorelix impurity
SB-075 ACETATE;NS-75A
Cetrorelix( x acetate)
Cetrorelix Acetate,SB-075 acetate,NS-75A, >98%
N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide acetic acid salt
D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-, acetate (salt) | [Molecular Formula]
C70H92ClN17O14.C2H4O2 | [MDL Number]
MFCD08459466 | [MOL File]
145672-81-7.mol | [Molecular Weight]
1491.11 |
| Hazard Information | Back Directory | [Description]
Cetrorelix is a synthetic peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with a Kd value of 0.2 nM for radioligand binding to murine LTK- cells expressing human GnRHR.1 It inhibits the activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells by the GnRHR agonist [D-Trp6]GnRH (IC50 = 1.2 nM). In vivo, cetrorelix (60 μg per day) reduces tumor volume to 35% of control and decreases serum luteinizing hormone levels by 50% in a human epithelial ovarian cancer mouse xenograft model.2 Centrorelix (0.5 mg/kg) protects the primordial follicles (PMF) in mouse ovaries from damage induced by cyclophosphamide (Item No. 13849) with 65% to 86% PMF survival compared to 46% PMF survival with a saline control.3 Formulations containing cetrorelix have been used to prevent ovulation during in vitro fertilization. | [Uses]
Cetrorelix Acetate is an gonadotropin-releasing hormone antagonist and is used to treat hormone-sensitive cancers of the prostate and breast. | [Definition]
ChEBI: The acetic acid salt of cetrorelix. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast. | [Biochem/physiol Actions]
Cetrorelix acetate is a luteinizing hormone releasing hormone receptor antagonist. It causes prepubertal reduction in bone modeling, bone density and bone strength comparable to post-menopausal bone loss. | [storage]
Store at -20°C |
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