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145701-23-1

145701-23-1 Structure

145701-23-1 Structure
IdentificationBack Directory
[Name]

FLORASULAM
[CAS]

145701-23-1
[Synonyms]

de-570
FLORASULAM
Florasulam [iso]
florasulam (bsi,iso)
FlorasμLam, 10 μg /μL in Acetonitrile
2',6'-difluoro-5-ethoxy-8-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonanilide
N-(2,6-Difluorophenyl)-8-fluoro-5-methoxy-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide
florasulam (ISO) 2',6',8-trifluoro-5-methoxy-5-triazolo[1,5-c] pyrimidine-2-sulfonanilide
[1,2,4]Triazolo[1,5-c]pyrimidine-2-sulfonamide, N-(2,6-difluorophenyl)-8-fluoro-5-methoxy-
[Molecular Formula]

C12H8F3N5O3S
[MDL Number]

MFCD08273843
[MOL File]

145701-23-1.mol
[Molecular Weight]

359.28
Chemical PropertiesBack Directory
[Melting point ]

220-221° (dec) (Van Heertum); also reported as 193.5-230.5° (Thompson)
[density ]

1.75±0.1 g/cm3(Predicted)
[storage temp. ]

0-6°C
[solubility ]

DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
[form ]

neat
[pka]

4.54(at 25℃)
[InChIKey]

QZXATCCPQKOEIH-UHFFFAOYSA-N
[LogP]

1.290 (est)
[EPA Substance Registry System]

[1,2,4]Triazolo[1,5-c]pyrimidine-2- sulfonamide, N-(2,6-difluorophenyl)-8-fluoro-5-methoxy- (145701-23-1)
Safety DataBack Directory
[Hazard Codes ]

N
[Risk Statements ]

50/53
[Safety Statements ]

60-61
[RIDADR ]

UN 3077 9 / PGIII
[WGK Germany ]

2
[Hazardous Substances Data]

145701-23-1(Hazardous Substances Data)
[Toxicity]

LD50 in rat, quail (mg/kg): >6000, 1046 orally; percutaneously in rabbit: >2000 mg/kg; LC50 in rainbow trout, bluegill (96 hr): >96, >98 mg/l (Thompson)
Questions And AnswerBack Directory
[Description]

Florasulam is a kind of selective triazolopyrimidine sulfonanilide post-emergent herbicide. It is absorbed by the foliage or roots of the plants. It acts as a systemic herbicide, being able to disrupt the internal growth processes of the weeds and causes their death in several weeks. It can be used for the control of broadleaf weeds in cereals. Its mechanism of action is through inhibiting the acetolactate synthase (ALS) in plants. The enzyme is present in the chloroplast and participates into the biosynthesis of branch chain amino acids such as valine, leucine and isoleucine. Through this mechanism, it can suppress plant cell division, plant growth and ultimately cause plant death. 
[References]

http://msdssearch.dow.com/PublishedLiteratureDOWCOM/dh_07cf/0901b803807cfdd2.pdf?filepath=productsafety/pdfs/noreg/233-00436.pdf&fromPage=GetDoc
http://www.agropages.com/AgroData/Detail-640.htm
Hazard InformationBack Directory
[Uses]

Herbicide.
[Definition]

ChEBI: Florasulam is a sulfonamide.
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