| Identification | Back Directory | [Name]
8-Bromo-2-(1-methyl-piperidin-4-ylamino)-4-(4-phenoxy-phenylamino)-6H-pyrido[4,3-d]pyrimidin-5-one hydrochloride | [CAS]
1457983-33-3 | [Synonyms]
G-749 hydrochloride
8-Bromo-2-(1-methyl-piperidin-4-ylamino)-4-(4-phenoxy-phenylamino)-6H-pyrido[4,3-d]pyrimidin-5-one hydrochloride | [Molecular Formula]
C25H26BrClN6O2 | [MDL Number]
MFCD23703605 | [MOL File]
1457983-33-3.mol | [Molecular Weight]
557.87 |
| Hazard Information | Back Directory | [Uses]
Denfivontinib (G-749) hydrochloride is an AXL inhibitor that has synergistic antitumor effects with the PD-1 inhibitor Pembrolizumab (HY-P9902). Denfivontinib can enhance the NOD-like receptor pathway, thereby promoting the formation of the NLRP3 inflammasome[1]. | [References]
[1] Kim DK, et al. Denfivontinib activates effector T-cells through NLRP3-inflammasome, yielding potent anticancer effects by combination with pembrolizumab. Mol Cancer Ther. 2024 Dec 5. DOI:10.1158/1535-7163.MCT-24-0501 |
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Twochem Co.Ltd
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www.twochem.com |
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