1458-63-5

110-89-4

109-70-6

1458-63-5

General procedure: 160 g (1.016 mol) of 1-bromo-3-chloropropane was added to the reactor at a temperature of 20±5°C with constant stirring. 86.1 g (1.011 mol) of piperidine was slowly added dropwise over a period of 2-3 hours. After completion of the dropwise addition, the reaction was continued with stirring for 1 hour. Subsequently, 100 mL of 30% sodium hydroxide solution was added and the reaction was continued for 4 hours. Upon completion of the reaction, a liquid-liquid separation was carried out and the organic phase was dried over anhydrous sodium sulfate. Finally, 127 g of 1-(3-chloropropyl)piperidine was obtained in 78.56% yield.