| Identification | Back Directory | [Name]
5-[(3-CHLOROPHENYL)-1H-IMIDAZOL-1-YLMETHYL]-1H-BENZIMIDAZOLE HYDROCHLORIDE | [CAS]
145858-50-0 | [Synonyms]
R75251
R-75251
R 75251
Liarozole HCl
Liarozole dihydrochl
LIAROZOLE HYDROCHLORIDE
5-[(3-CHLOROPHENYL)-1H-IMIDAZOL-1-YLMETHYL]-1H-BENZIMIDAZOLE HYDROCHLORIDE | [Molecular Formula]
C17H14Cl2N4 | [MDL Number]
MFCD00879803 | [MOL File]
145858-50-0.mol |
| Hazard Information | Back Directory | [Uses]
Antineoplastic. | [Uses]
Liarozole Hydrochloride is a Imidazole-containing compound that inhibits the cytochrome P450-dependent metabolism. | [Biological Activity]
Cytochrome P450 inhibitor. Inhibits several cytochrome P450 enzymes including aromatase (CYP19) and retinoic acid 4-hydroxylase (CYP26). Blocks retinoic acid metabolism (retinoic acid metabolism blocking agent, RAMBA). Displays antitumor activity against androgen-dependent and independent rat prostate carcinomas. | [in vivo]
Liarozole (5-20 mg/kg; p.o.; 3 days) reverses the vaginal keratosis caused by estrogen stimulation[5].
Liarozole (40 mg/kg; p.o.; 21 days) reduces tumor burden substantially[6]. | Animal Model: | Ovariectomized rats[5] | | Dosage: | 5~20 mg/kg | | Administration: | P.o.; 3 days | | Result: | Reversed the vaginal keratosis caused by estrogen stimulation. |
| Animal Model: | SCID mice[6] | | Dosage: | 40 mg/kg | | Administration: | P.o.; 21 days | | Result: | Inhibited tumor growth and survival. |
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Energy Chemical
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