| Identification | Back Directory | [Name]
5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE | [CAS]
145915-60-2 | [Synonyms]
DAPH 2
DAPH-7
CGP 53353
CGP-53353 solid
PKCβII/EGFR Inhibitor - CAS 145915-60-2 - Calbiochem
5,6-BIS[(4-FLUOROPHENYL)AMINO]-2H-ISOINDOLE-1,3-DIONE
5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]-
5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione, DAPH 2 | [Molecular Formula]
C20H13F2N3O2 | [MDL Number]
MFCD00938569 | [MOL File]
145915-60-2.mol | [Molecular Weight]
365.33 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: >10mg/mL | [form ]
solid | [color ]
orange | [InChI]
1S/C20H13F2N3O2/c21-11-1-5-13(6-2-11)23-17-9-15-16(20(27)25-19(15)26)10-18(17)24-14-7-3-12(22)4-8-14/h1-10,23-24H,(H,25,26,27) | [InChIKey]
RONQPWQYDRPRGG-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Uses]
CGP 53353 inhibited tyrosine kinase activity of the EGF-R in five different human transitional cell carcinoma lines. | [Definition]
ChEBI: 5,6-bis(4-fluoroanilino)isoindole-1,3-dione is a member of phthalimides. | [Biological Activity]
Selective inhibitor of PKC β II (IC 50 values are 0.41 and 3.8 μ M for PKC β II and PKC β I respectively). Also inhibits prionogenic Sup35 fibrillization (IC 50 ~ 3.4 μ M) and inhibits de novo A β 42 assembly in vitro . | [IC 50]
PKCβII: 0.41 mM (IC50); PKCβI: 3.8 mM (IC50) | [storage]
Store at RT |
|
| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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