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145927-73-7

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145927-73-7 Structure

145927-73-7 Structure
IdentificationBack Directory
[Name]

Mes-PEG5- THP
[CAS]

145927-73-7
[Synonyms]

MS-PEG4-THP
Mes-PEG5- THP
Mes-PEG4- THP
CAS_145927-73-7
Ethanol, 2-[2-[2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethoxy]ethoxy]ethoxy]-, 1-methanesulfonate
[Molecular Formula]

C14H28O8S
[MDL Number]

MFCD29049413
[MOL File]

145927-73-7.mol
[Molecular Weight]

356.43
Hazard InformationBack Directory
[Biological Activity]

MS-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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