| Identification | Back Directory | [Name]
Benzamide, 3-[[5-bromo-4-[4-(trifluoromethyl)phenyl]-2-oxazolyl]methoxy]-2,6-difluoro- | [CAS]
1459695-66-9 | [Synonyms]
Benzamide, 3-[[5-bromo-4-[4-(trifluoromethyl)phenyl]-2-oxazolyl]methoxy]-2,6-difluoro- 3-({5-bromo-4-[4-(trifluoromethyl)phenyl]-1,3-oxazol-2-yl}methoxy)-2,6-difluorobenzamide 3-[[5-Bromanyl-4-[4-(Trifluoromethyl)phenyl]-1,3-Oxazol-2-Yl]methoxy]-2,6-Bis(Fluoranyl)benzamide | [Molecular Formula]
C18H10BrF5N2O3 | [MOL File]
1459695-66-9.mol | [Molecular Weight]
477.18 |
| Hazard Information | Back Directory | [Uses]
TXA6101 is a bacterial protein FtsZ (filamentous temperature-sensitive protein Z) inhibitor that inhibits bacterial division. TXA6101 has antimicrobial activity against MRSA isolates expressing either the G193D or G196S mutant FtsZ with the MIC value of 1 μg/mL, retains significant activity against the TXA707-resistant FtsZ mutant. TXA6101 can be used as a potential method against Gram-negative bacterial infections[1][2]. | [References]
[1] Andrea Casiraghi, et al. Targeting Bacterial Cell Division: A Binding Site-Centered Approach to the Most Promising Inhibitors of the Essential Protein FtsZ. Antibiotics (Basel). 2020 Feb 7;9(2):69. DOI:10.3390/antibiotics9020069 [2] Junso Fujita, et al. Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ. ACS Chem Biol. 2017 Jul 21;12(7):1947-1955. DOI:10.1021/acschembio.7b00323 [3] Jesus D Rosado-Lugo, et al. Evaluation of 2,6-difluoro-3-(oxazol-2-ylmethoxy)benzamide chemotypes as Gram-negative FtsZ inhibitors. J Antibiot (Tokyo). 2022 Jul;75(7):385-395. DOI:10.1038/s41429-022-00531-9 |
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| Company Name: |
Biorbyt Ltd.
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| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
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