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1459695-66-9

1459695-66-9 Structure

1459695-66-9 Structure
IdentificationBack Directory
[Name]

Benzamide, 3-[[5-bromo-4-[4-(trifluoromethyl)phenyl]-2-oxazolyl]methoxy]-2,6-difluoro-
[CAS]

1459695-66-9
[Synonyms]

Benzamide, 3-[[5-bromo-4-[4-(trifluoromethyl)phenyl]-2-oxazolyl]methoxy]-2,6-difluoro-
3-({5-bromo-4-[4-(trifluoromethyl)phenyl]-1,3-oxazol-2-yl}methoxy)-2,6-difluorobenzamide
3-[[5-Bromanyl-4-[4-(Trifluoromethyl)phenyl]-1,3-Oxazol-2-Yl]methoxy]-2,6-Bis(Fluoranyl)benzamide
[Molecular Formula]

C18H10BrF5N2O3
[MOL File]

1459695-66-9.mol
[Molecular Weight]

477.18
Chemical PropertiesBack Directory
[Boiling point ]

477.5±45.0 °C(Predicted)
[density ]

1.632±0.06 g/cm3(Predicted)
[pka]

14.16±0.50(Predicted)
Hazard InformationBack Directory
[Uses]

TXA6101 is a bacterial protein FtsZ (filamentous temperature-sensitive protein Z) inhibitor that inhibits bacterial division. TXA6101 has antimicrobial activity against MRSA isolates expressing either the G193D or G196S mutant FtsZ with the MIC value of 1 μg/mL, retains significant activity against the TXA707-resistant FtsZ mutant. TXA6101 can be used as a potential method against Gram-negative bacterial infections[1][2].
[References]

[1] Andrea Casiraghi, et al. Targeting Bacterial Cell Division: A Binding Site-Centered Approach to the Most Promising Inhibitors of the Essential Protein FtsZ. Antibiotics (Basel). 2020 Feb 7;9(2):69. DOI:10.3390/antibiotics9020069
[2] Junso Fujita, et al. Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ. ACS Chem Biol. 2017 Jul 21;12(7):1947-1955. DOI:10.1021/acschembio.7b00323
[3] Jesus D Rosado-Lugo, et al. Evaluation of 2,6-difluoro-3-(oxazol-2-ylmethoxy)benzamide chemotypes as Gram-negative FtsZ inhibitors. J Antibiot (Tokyo). 2022 Jul;75(7):385-395. DOI:10.1038/s41429-022-00531-9
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