| Identification | Back Directory | [Name]
Oosponol | [CAS]
146-04-3 | [Synonyms]
Oosponol
Lenzitin
Brn 1287762
4-Glycolyl-8-hydroxyisocoumarin
Isocoumarin, 4-glycolyl-8-hydroxy-
4-(1-Oxo-2-hydroxyethyl)-8-hydroxyisocoumarin
8-Hydroxy-4-(hydroxyacetyl)-1H-2-benzopyran-1-one | [MDL Number]
MFCD01718127 | [MOL File]
146-04-3.mol |
| Hazard Information | Back Directory | [Uses]
Oosponol is a dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects.Oospongol has strong antifungal activity against many antagonistic fungi[1][2]. | [in vivo]
Oosponol (6.25 mg/kg, 3.1 mg/kg, ip, Once) can lower blood pressure in spontaneously hypertensive rats model[1]. | Animal Model: | Spontaneously hypertensive rats[1] | | Dosage: | 6.25 mg/kg, 3.1 mg/kg | | Administration: | Intraperitoneal injection, once. | | Result: | The intraperitoneal injection of 6.25 mg/kg lowered the pressure from 186 mm to 138~112 mm, the intraperitoneal injection of 3.1 mg/kg lowered the pressure from 185 mm to 164~131 mm[1]. |
| Animal Model: | Spontaneously hypertensive rats[1] | | Dosage: | 6.25 mg/kg, 3.1 mg/kg | | Administration: | Intraperitoneal injection, once. | | Result: | The intraperitoneal injection of 6.25 mg/kg lowered the pressure from 186 mm to 138~112 mm, the intraperitoneal injection of 3.1 mg/kg lowered the pressure from 185 mm to 164~131 mm. |
| [References]
[1] Umezawa H, et al.. Dopamine -hydroxylase inhibitor produced by Gloeophyllum striatum and its identity with oosponol. J Antibiot (Tokyo). 1972 Apr;25(4):239-42. DOI:10.7164/antibiotics.25.239
[2] Sonnenbichler J,et al. Influence of the Gloeophyllum metabolite oosponol and some synthetic analogues on protein and RNA synthesis in target cells. Eur J Biochem. 1997 May 15;246(1):45-9. DOI:10.1111/j.1432-1033.1997.t01-2-00045.x |
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