| Identification | Back Directory | [Name]
SC-51322 | [CAS]
146032-79-3 | [Synonyms]
SC-51322
8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic Acid 2-[3-[(2-FuranylMethyl) thio]-1-oxopropyl]hydrazide
8-Chloro-2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]-dibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylicacidhydrazide
Dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]hydrazide | [Molecular Formula]
C22H20ClN3O4S | [MDL Number]
MFCD00916246 | [MOL File]
146032-79-3.mol | [Molecular Weight]
457.93 |
| Chemical Properties | Back Directory | [Melting point ]
112-114°C | [RTECS ]
HQ4002000 | [storage temp. ]
Store at +4°C | [solubility ]
DMSO: ≥10mg/mL | [form ]
powder | [color ]
white to off-white |
| Hazard Information | Back Directory | [Description]
The prostaglandin E2 (PGE2) receptor (EP1) is involved in triggering PGE2-mediated pain as well as neuronal survival and growth. SC-51322 is a selective EP1 antagonist that inhibits PGE2 signaling in a guinea pig ileum muscle strip assay with a pA2 value of 8.1 and demonstrates analgesic activity in a mouse writhing assay with an ED50 value of 0.9 mg/kg. It is pharmacologically similar to SC-51089, but does not release hydrazine, a known carcinogen to rats, as does SC-51089. SC-51322 potentiates the vasorelaxation of human pulmonary vein induced by PGE2 with an EC50 value of 7.75 μM. | [Chemical Properties]
Off-White Solid | [Uses]
A selective E-prostanoid receptor subtype 1 (EP1) receptor antagonist which shows antihypertensive effects. | [IC 50]
EP2: 8.1 (pA2) | [storage]
Store at -20°C | [References]
[1] E. ANN HALLINAN. Aminoacetyl Moiety as a Potential Surrogate for Diacylhydrazine Group of SC-51089, a Potent PGE2 Antagonist, and Its Analogs[J]. Journal of Medicinal Chemistry, 1996, 39 2: 609-613. DOI: 10.1021/jm950454k
[2] N FOUDI. Vasorelaxation induced by prostaglandin E2 in human pulmonary vein: role of the EP4 receptor subtype[J]. British Journal of Pharmacology, 2009, 154 8: 1631-1639. DOI: 10.1038/bjp.2008.214 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|