| Identification | Back Directory | [Name]
(S)-4,6-difluoro-5-(4-(tetrahydro-2H-pyran-2-yl)phenyl)-1H-indole-3-carboxylic acid | [CAS]
1467059-66-0 | [Synonyms]
PF6679142
PF-6679142
PF 6679142
PF-06679142
(S)-4,6-difluoro-5-(4-(tetrahydro-2H-pyran-2-yl)phenyl)-1H-indole-3-carboxylic acid
1H-Indole-3-carboxylic acid, 4,6-difluoro-5-[4-[(2S)-tetrahydro-2H-pyran-2-yl]phenyl]- | [Molecular Formula]
C20 H17 F2 N O3 | [MOL File]
1467059-66-0.mol | [Molecular Weight]
357.35 |
| Chemical Properties | Back Directory | [Boiling point ]
573.1±50.0 °C(Predicted) | [density ]
1.372±0.06 g/cm3(Predicted) | [pka]
2.00±0.30(Predicted) | [InChI]
InChI=1S/C20H17F2NO3/c21-14-9-15-18(13(10-23-15)20(24)25)19(22)17(14)12-6-4-11(5-7-12)16-3-1-2-8-26-16/h4-7,9-10,16,23H,1-3,8H2,(H,24,25)/t16-/m0/s1 | [InChIKey]
JQJNGAWEMYQJIQ-INIZCTEOSA-N | [SMILES]
N1C2=C(C(F)=C(C3=CC=C([C@H]4OCCCC4)C=C3)C(F)=C2)C(C(O)=O)=C1 |
| Hazard Information | Back Directory | [Uses]
PF-06679142 (Compound 10) is a potent, orally active AMPK activator with an EC50 of 22 nM against α1β1γ1-AMPK. PF-06679142 can be used for diabetic nephropathy research[1]. | [IC 50]
AMPK α1β1γ1: 22 nM (EC50) | [References]
[1] Edmonds DJ, et al. Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem. 2018 Mar 22;61(6):2372-2383. DOI:10.1021/acs.jmedchem.7b01641 |
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