| Chemical Properties | Back Directory | [Boiling point ]
540.9±50.0 °C(Predicted) | [density ]
1.400±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (289.20 mM; Need ultrasonic) | [form ]
Solid | [pka]
3.15±0.30(Predicted) | [color ]
Off-white to gray |
| Hazard Information | Back Directory | [Uses]
PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research[1]. | [IC 50]
AMPK α1β1γ1: 12 nM (EC50) | [storage]
Store at -20°C | [References]
[1] David J Edmonds, et al. Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem. 2018 Mar 22;61(6):2372-2383. DOI:10.1021/acs.jmedchem.7b01641 |
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