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146939-64-2

146939-64-2 Structure

146939-64-2 Structure
IdentificationBack Directory
[Name]

3-Indolizinebutanoic acid, 1-[4-[(1S)-1-[4-(2-methylpropyl)phenyl]butoxy]benzoyl]-
[CAS]

146939-64-2
[Synonyms]

FK687
TF505
TF-505
FK-687
TF 505
FR-146687
3-Indolizinebutanoic acid, 1-[4-[(1S)-1-[4-(2-methylpropyl)phenyl]butoxy]benzoyl]-
[Molecular Formula]

C33H37NO4
[MOL File]

146939-64-2.mol
[Molecular Weight]

511.65
Chemical PropertiesBack Directory
[density ]

1.12±0.1 g/cm3(Predicted)
[pka]

4.75±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

FR-146687 (FK 687) is a selective and orally active 5α-reductase inhibitor with IC50s of 1.7 nM and 4.6 nM for rat and human 5α-reductases, respectively. FR-146687 shows no inhibitory effects on other steroid oxidoreductases[1].
[in vivo]

FR-146687 (0.032-3.2 mg/kg; po; 2, 7, 14, or 21 days) dose-dependently reduces ventral prostate and seminal vesicle weight at doses above 0.1 mg/kg[1].

Animal Model:4-week-old immature castrated male rats injected with Testosterone propionate (TP)[1]
Dosage:0.032 mg/kg, 0.32 mg/kg, 3.2 mg/kg
Administration:po; 2, 7, 14, or 21 days
Result:Dose-dependently reduced ventral prostate and seminal vesicle weight at doses above 0.1 mg/kg.
[References]

[1] O Nakayama, et al. FR146687, a novel steroid 5 alpha-reductase inhibitor: in vitro and in vivo effects on prostates. Prostate. 1997 Jun 1;31(4):241-9. DOI:10.1002/(sici)1097-0045(19970601)31:4<241::aid-pros5>3.0.co;2-n
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