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1470023-72-3

1470023-72-3 Structure

1470023-72-3 Structure
IdentificationBack Directory
[Name]

D-?Ribitol, 1,?4-?anhydro-?5-?O-?[bis(4-?methoxyphenyl)?phenylmethyl]?-?2-?O-?methyl-?, 3-?[2-?cyanoethyl N,?N-?bis(1-?methylethyl)?phosphoramidite]
[CAS]

1470023-72-3
[Synonyms]

DMT-2'-OMe-D-Ribitol phosphoramidite
(2R,3S,4S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
D-Ribitol, 1,4-anhydro-5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-O-methyl-, 3-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] (ACI)
D-?Ribitol, 1,?4-?anhydro-?5-?O-?[bis(4-?methoxyphenyl)?phenylmethyl]?-?2-?O-?methyl-?, 3-?[2-?cyanoethyl N,?N-?bis(1-?methylethyl)?phosphoramidite]
[Molecular Formula]

C36H47N2O7P
[MOL File]

1470023-72-3.mol
[Molecular Weight]

650.75
Chemical PropertiesBack Directory
[Boiling point ]

675.3±55.0 °C(Predicted)
[pka]

3.45±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

DMT-2'-OMe-D-Ribitol phosphoramidite (compound 9) is an abasic phosphoramidite monomer that can be used to introduce the abasic group Y34 into oligonucleotides[1].
[References]

[1] Liu J, et al. RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression. Nucleic Acids Res. 2013 Oct;41(18):8788-801. DOI:10.1093/nar/gkt594
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