| Identification | Back Directory | [Name]
(2-Hydroxyphenyl)acetonitrile | [CAS]
14714-50-2 | [Synonyms]
(2-Hydroxyphenyl)acetonitrile
2-(2-hydroxyphenyl)acetonitrile
Benzeneacetonitrile, 2-hydroxy- | [Molecular Formula]
C8H7NO | [MOL File]
14714-50-2.mol | [Molecular Weight]
133.15 |
| Chemical Properties | Back Directory | [Melting point ]
122-123℃ | [Boiling point ]
285.2±15.0℃ (760 Torr) | [density ]
1.167±0.06 g/cm3 (20 ºC 760 Torr) | [Fp ]
126.3±20.4℃ | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
9.46±0.30(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 41, p. 2502, 1976 DOI: 10.1021/jo00876a038 | [Synthesis]
In a 2L round bottom flask reactor, salicyl alcohol (100 g, 806 mmol), sodium cyanide (43.4 g, 886 mmol) and dimethylformamide (1000 mL) were added and the mixture was stirred and reacted at 120°C for 4 hours. Upon completion of the reaction, extraction was carried out using water and ethyl acetate. The organic phase was concentrated and purified by column chromatography to afford 2-hydroxyphenylacetonitrile (90 g, 84% yield). | [References]
[1] Patent: CN107459523, 2017, A. Location in patent: Paragraph 0285; 0286; 0287; 0288; 0289
[2] Patent: KR2018/14985, 2018, A. Location in patent: Paragraph 0550-0556
[3] Patent: KR2016/26661, 2016, A. Location in patent: Paragraph 0455-0461
[4] Tetrahedron, 2015, vol. 71, # 26-27, p. 4432 - 4437 |
|
|