| Identification | Back Directory | [Name]
Flibanserin Hydrochloride | [CAS]
147359-76-0 | [Synonyms]
Flibanserin HCl
Flibanserin iMpurity
Flibanserin Hydrochloride
Flibanserin Hydrochloride USP/EP/BP
2H-Benzimidazol-2-one,1,3-dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-,hydrochloride (1:1) | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C20H21F3N4O.HCl | [MDL Number]
MFCD29058559 | [MOL File]
147359-76-0.mol | [Molecular Weight]
426.863 |
| Chemical Properties | Back Directory | [Melting point ]
>225°C (dec.) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Pale Yellow | [InChI]
InChI=1S/C20H21F3N4O.ClH/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28;/h1-7,14H,8-13H2,(H,24,28);1H | [InChIKey]
XGAGFLQFMFCIHZ-UHFFFAOYSA-N | [SMILES]
C(N1C(NC2C=CC=CC1=2)=O)CN1CCN(C2C=CC=C(C(F)(F)F)C=2)CC1.Cl |
| Hazard Information | Back Directory | [Uses]
Flibanserin is a 5-HT1A agonist and 5-HT2A antagonist that is developed for the treatment of hypoactive sexual desire disorder in women (1,2). | [Synthesis]
The one-pot reaction of benzaldehyde, N-phenylhydroxylamine and trimethylcyanosilane facilitated by iodobenzene acetate first builds the important backbone benzimidazolone structure of flubanserin, and then reacts with 1,2-dibromoethane to give intermedia |
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