| Identification | Back Directory | [Name]
1,4-dihydroxy-3-methyl-2-naphthyl 4-aminobenzoate | [CAS]
14748-94-8 | [Synonyms]
Menatriol
Capilarema
Aminaftone
Capillarema
Aminaphthone
Einecs 238-809-8
1,4-dihydroxy-3-methyl-2-naphthyl 4-aminobenzoate
3-Methyl-1,2,4-naphthalenetriol-2-(4-aminobenzoate)
1,2,4-Naphthalenetriol, 3-methyl-, 2-(4-aminobenzoate)
4-Aminobenzoic acid 1,4-dihydroxy-3-methylnaphthalen-2-yl ester | [EINECS(EC#)]
238-809-8 | [Molecular Formula]
C18H15NO4 | [MDL Number]
MFCD27965861 | [MOL File]
14748-94-8.mol | [Molecular Weight]
309.32 |
| Chemical Properties | Back Directory | [Boiling point ]
617.1±55.0 °C(Predicted) | [density ]
1.390±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
8.00±0.50(Predicted) |
| Hazard Information | Back Directory | [Uses]
Aminaftone, a derivative of 4-aminobenzoic acid, downregulates endothelin-1 (ET-1) production in vitro by interfering with the transcription of the pre-pro-ET-1 gene. | [Definition]
ChEBI: Aminaphthone is a member of naphthols. | [in vivo]
The rats are randomly assigned to the following experimental groups: Control; Monocrotaline; Aminaftone 30 mg/kg/day; Aminaftone 150 mg/kg/day. After 5 weeks, mortality is significantly lower in the animals treated with Aminaftone at both doses compared to Monocrotaline alone. Aminaftone reduces plasma concentration of ET-1 and seems to reduce right heart hypertrophy and the wall thickness of the pulmonary arteries at the highest dose. At the end of the experiment, no rats die in the control and Aminaftone 150 groups, while mortality is 38% in the Monocrotaline group and 13% in the Aminaftone 30 group. Overall, Aminaftone treated rats have a significantly lower mortality compared to rats in the Monocrotaline group (P=0.044)[2]. | [storage]
Store at -20°C | [References]
[1] Scorza R, et al. Aminaftone, a derivative of 4-aminobenzoic acid, downregulates endothelin-1 production in ECV304 Cells: an in vitro Study. Drugs R D. 2008;9(4):251-7. DOI:10.2165/00126839-200809040-00005
[2] Zambelli V, et al. Efficacy of aminaftone in a rat model of monocrotaline-induced pulmonary hypertension. Eur J Pharmacol. 2011 Sep 30;667(1-3):287-91. DOI:10.1016/j.ejphar.2011.05.060 |
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