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147816-23-7

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147816-23-7 Structure

147816-23-7 Structure
IdentificationBack Directory
[Name]

Cefcapene Pivoxil Hydrochloride
[CAS]

147816-23-7
[Synonyms]

(6R,7R)-(Pivaloyloxy)methyl 7-((Z)-2-(2-aminothiazol-4-yl)pent-2-enamido)-3-((carbamoyloxy)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-(((2Z)-2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl)amino)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, (6R,7R)-
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl)amino)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, (6R-(6alpha,7beta(Z)))-
[Molecular Formula]

C23H30ClN5O8S2
[MDL Number]

MFCD01682041
[MOL File]

147816-23-7.mol
[Molecular Weight]

604.096
Chemical PropertiesBack Directory
[Melting point ]

158-164°C
[storage temp. ]

Inert atmosphere,Store in freezer, under -20°C
[solubility ]

DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
[form ]

Solid
[color ]

White to Pale Beige
Hazard InformationBack Directory
[Chemical Properties]

White to Off-White Solid
[Uses]

Antibacterial. Orally absorbed cephalosporin; ester prodrug of the active free acid metabolite, cefcapene.
[in vivo]

Cefcapene pivoxil hydrochloride (oral administration; 100mg/kg; 4 days) is effective against invasive BLNAR strains in mice lung, stimates peak antibiotic concentrations of 1 to 2 μg/ml?in the blood of mice from 30 to 120 min after intragastric administration[3].

Animal Model:Four-week-old female C57BL/6J mice with bacterial suspension in BSG (1×109?CFU)[3]
Dosage:100 mg/kg
Administration:Oral administration; 100mg/kg; 4 days
Result:Was against?H. influenzae?colonization in mouse lung.
[IC 50]

β-lactam
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