| Identification | Back Directory | [Name]
12(S)-HYDROXY-16-HEPTADECYNOIC ACID | [CAS]
148019-74-3 | [Synonyms]
12(S)-HYDROXY-16-HEPTADECYNOIC ACID
16-Heptadecynoic acid, 12-hydroxy-, (S)- (9CI)
12(S)hydroxy16Heptadecynoic Acid,12(S) hydroxy 16 Heptadecynoic Acid | [Molecular Formula]
C17H30O3 | [MDL Number]
MFCD00216120 | [MOL File]
148019-74-3.mol | [Molecular Weight]
282.42 |
| Chemical Properties | Back Directory | [Boiling point ]
432.8±20.0 °C(Predicted) | [density ]
0.989±0.06 g/cm3(Predicted) | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml | [form ]
A crystalline solid | [pka]
4.78±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
12(S)-hydroxy-16-Heptadecynoic acid is a mechanism-based inhibitor of cytochrome P450 ω-hydroxylase. It inhibits prostaglandin ω-hydroxylase with a Ki value of 1.8 μM. | [Uses]
12(S)-Hydroxy-16-heptadecynoic acid ((12S)-12-Hydroxy-15-hexadecynoic acid) is a mechanism-based inhibitor of cytochrome P450 ω-hydroxylase. It inhibits prostaglandin ω-hydroxylase with a Ki value of 1.8 μM. | [Definition]
ChEBI: 12S-Hydroxy-16-heptadecynoic acid is a long-chain fatty acid. | [References]
[1] Burger, et al. Mechanism-based inhibitors of prostaglandin w -hydrolase: (R)- and (S)-12-hydroxy-16-heptadecynoic acid and 2,2-dimethyl-12-hydroxy-16-heptadecynoic acid. J. Med. Chem. 36, 1418-1424 (1993). |
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