| Identification | Back Directory | [Name]
6-BROMO-1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONE | [CAS]
148038-83-9 | [Synonyms]
6-Bromo-1H-imidazo[4,5-b]pyridin-2-ol
6-Bromo-1H-imidazo[4,5-b]pyridin-2(3H)
6-Bromoimidazo[4,5-b]pyridin-2(3H)-one
6-BROMO-1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONE
6-broMo-1H,2H,3H-iMidazo[4,5-b]pyridin-2-one
6-Bromo-1,3-dihydro-imidazo[4,5-b]pyridin-2-one
6-BROMO-1,3-DIHYDRO-2H-IMIDAZO[4,5-B]PYRIDIN-2-ONE
2H-IMidazo[4,5-b]pyridin-2-one, 6-broMo-1,3-dihydro- | [Molecular Formula]
C6H4BrN3O | [MDL Number]
MFCD00763285 | [MOL File]
148038-83-9.mol | [Molecular Weight]
214.02 |
| Chemical Properties | Back Directory | [Melting point ]
>350° | [Boiling point ]
189℃ | [density ]
1.837 | [Fp ]
68℃ | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
11.36±0.20(Predicted) | [Appearance]
White to gray Solid |
| Hazard Information | Back Directory | [Synthesis]
To a solution of 2,3-diamino-5-bromopyridine (5 g, 27 mmol) in tetrahydrofuran (THF, 87 mL) was added N,N'-carbonyl diimidazole (CDI, 3.02 g, 18.6 mmol). The reaction mixture was stirred at 80 °C for 16 hours. Upon completion of the reaction, water was added to quench the reaction and the mixture was filtered. The solid product was collected, washed sequentially with water and ether (Et2O), and dried under vacuum to afford 6-bromo-1H-imidazo[4,5-B]pyridin-2(3H)-one (5.3 g, 25 mmol, 93% yield), and the product could be used in subsequent reactions without further purification. Mass spectrometry (ESI) analysis: calculated value (C6H4BrN3O) 212.95; measured value, 214 [M + H]+. | [References]
[1] Patent: WO2018/67786, 2018, A1. Location in patent: Page/Page column 106
[2] Patent: WO2010/121164, 2010, A2. Location in patent: Page/Page column 61
[3] Patent: WO2011/149950, 2011, A2. Location in patent: Page/Page column 104-105 |
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