| Identification | Back Directory | [Name]
1-O-Hexyl-2,3,5-trimethylhydroquinone | [CAS]
148081-72-5 | [Synonyms]
HX-1171
CS-2408
4-hexoxy-2
1-O-Hexyl-2
HX-1171(HTHQ)
HTHQ(HX-1171)
6-trimethylphenol
5-trimethylhydroquinone
HEXYLOXY TRIMETHYLPHENOL
4-hexoxy-2,3,6-trimethylphenol
4-Hexyloxy-2,3,6-triMethylphenol
4-(Hexyloxy)-2,3,6-triMethyl-phenol
Phenol, 4-(hexyloxy)-2,3,6-trimethyl-
HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)
4-HEXOXY-2;3;6-TRIMETHYLPHENOL;1-O-HEXYL-2;3;5-TRIMETHYLHYDROQUINONE
BTT 105,BTT105,inhibit,BTT-105,HTHQ,HX1171,Reactive Oxygen Species,Inhibitor,HX-1171 | [Molecular Formula]
C15H26O2 | [MDL Number]
MFCD00927896 | [MOL File]
148081-72-5.mol | [Molecular Weight]
238.368 |
| Chemical Properties | Back Directory | [Melting point ]
72.5-73°C | [Boiling point ]
357.8±37.0 °C(Predicted) | [density ]
0.971±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform：soluble | [form ]
powder to crystal | [pka]
11.22±0.30(Predicted) | [color ]
White to Light yellow to Dark green | [LogP]
5.255 (est) |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Low Melting Solid | [Uses]
A novel phenolic antioxidant that showed strong antimutagenic activity against eight carcinogenic heterocyclic amines (HCA), produced during cooking processes. Its antimutagenic activity appeared to inhibit both metabolic activation of HCA and action on activated N-Hydroxy species. | [in vivo]
HTHQ (50-200 mg/kg; oral administration; for 4 weeks; specific pathogen-free male Sprague Dawley rats) treatment significantly improves liver weight and serum chemistry level. HTHQ reduces hydroxyproline and malondialdehyde level in the liver. HTHQ treatment also reduces fibrotic septa. HTHQ administration shows reduced mRNA level of PDGF (Plateletderived growth factor) , α-SMA (α-smooth muscle actin) and TGF-β (transforming growth factor-β) than DMN-induced hepetic fibrosis animals in the liver tissue[2]. | Animal Model: | 48 specific pathogen-free male Sprague Dawley (SD) rats (6-week-old ) with dimethylnitrosamine (DMN) [2] | | Dosage: | 50 mg/kg, 100 mg/kg, 200 mg/kg | | Administration: | Oral administration; for 4 weeks | | Result: | Improved against DMN-induced liver fibrosis in male SD rats.
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| [References]
[1] Park HJ, et al. 1-O-Hexyl-2,3,5-Trimethylhydroquinone Ameliorates l-DOPA-Induced Cytotoxicity in PC12 Cells. Molecules. 2019 Mar 1;24(5). pii: E867. DOI:10.3390/molecules24050867
[2] Jung YR et al. Inhibitory Effect of 1-O-Hexyl-2,3,5-Trimethylhydroquinone on Dimethylnitrosamine-induced Liver Fibrosis in Male SD Rats. Toxicol Res. 2010 Sep;26(3):193-201. DOI:10.5487/TR.2010.26.3.193 |
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