| Identification | Back Directory | [Name]
5-BROMO-2-METHOXYPYRIMIDIN-4-YLAMINE | [CAS]
148214-56-6 | [Synonyms]
5-Bromo-2-methoxypyrimidin-4-amine
5-BROMO-2-METHOXYPYRIMIDIN-4-YLAMINE
4-Pyrimidinamine, 5-bromo-2-methoxy-
5-BROMO-2-METHOXYPYRIMIDIN-4-YLAMINE ISO 9001：2015 REACH | [Molecular Formula]
C5H6BrN3O | [MDL Number]
MFCD09953511 | [MOL File]
148214-56-6.mol | [Molecular Weight]
204.02 |
| Chemical Properties | Back Directory | [Melting point ]
134-136 °C | [Boiling point ]
332.3±45.0 °C(Predicted) | [density ]
1.723±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
3.35±0.10(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
To a methanolic (1 L) suspension of 5-bromo-2-chloropyrimidin-4-amine (137.3 g, 658 mmol) was added sodium methanolate (83.5 g, 1.54 mol) in batches. The reaction mixture was stirred under reflux conditions for 2 hours. Upon completion of the reaction, the mixture was concentrated to about 400 mL and poured into saturated aqueous ammonium chloride solution (1.2 L). After stirring for 15 minutes, the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated to give 5-bromo-2-methoxypyrimidin-4-amine (133.7 g, 99.4% yield). | [References]
[1] Patent: WO2015/155042, 2015, A1. Location in patent: Page/Page column 24; 25
[2] Patent: WO2016/166255, 2016, A1. Location in patent: Page/Page column 29 |
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NovoChemy Ltd.
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www.novochemy.com |
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