| Identification | Back Directory | [Name]
N-[[(5S)-3-[3-Fluoro-4-(1-pyrrolidinyl)phenyl]-4,5-dihydro-5-isoxazolyl]methyl]-2-propanesulfonamide | [CAS]
1488407-52-8 | [Synonyms]
PF-04701475
PF-04701475 >=98% (HPLC)
N-[[(5S)-3-[3-Fluoro-4-(1-pyrrolidinyl)phenyl]-4,5-dihydro-5-isoxazolyl]methyl]-2-propanesulfonamide
2-Propanesulfonamide, N-[[(5S)-3-[3-fluoro-4-(1-pyrrolidinyl)phenyl]-4,5-dihydro-5-isoxazolyl]methyl]- | [Molecular Formula]
C17H24FN3O3S | [MDL Number]
MFCD28100802 | [MOL File]
1488407-52-8.mol | [Molecular Weight]
369.45 |
| Chemical Properties | Back Directory | [Boiling point ]
513.0±60.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: soluble5mg/mL, clear | [form ]
powder | [pka]
10.87±0.40(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
PF-04701475 is a potent AMPA receptor potentiator with an EC50 of 123 nM. PF-04701475 can be used for the study of neurological disorders[1]. | [Biological Activity]
PF-04701475 is a potent and selective α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) positive allosteric potentiator. | [References]
[1] Nandini C Patelm et al. Discovery and characterization of a novel dihydroisoxazole class of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiators. J Med Chem. 2013 Nov 27;56(22):9180-91. DOI:10.1021/jm401274b |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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