| Identification | Back Directory | [Name]
KI-7 | [CAS]
1489263-00-4 | [Synonyms]
KI-7
KI-74
1H-Indole-3-acetamide, α-oxo-N-phenyl-1-(phenylmethyl)-
potentiate,Runx2,Osterix,KI7,KI 7,Inhibitor,P1 receptor,inhibit,orthosteric,MSC,cAMP,accumulation,KI-7,Adenosine Receptor,allosteric | [Molecular Formula]
C23H18N2O2 | [MDL Number]
MFCD34470323 | [MOL File]
1489263-00-4.mol | [Molecular Weight]
354.41 |
| Chemical Properties | Back Directory | [density ]
1.18±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
10.93±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
KI-7 is an A2B adenosine receptor positive allosteric modulator. KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC50=445.8 nM). KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC50s of 2390 nM and 2550 nM, respectively[1][2]. | [storage]
Store at +4°C | [References]
[1] Trincavelli ML, et al. Allosteric modulators of human A2B adenosine receptor. Biochim Biophys Acta. 2014;1840(3):1194-1203. DOI:10.1016/j.bbagen.2013.12.021
[2] Trincavelli ML, et al. Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. Biochim Biophys Acta. 2014;1843(12):2957-2966. DOI:10.1016/j.bbamcr.2014.09.013 |
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