149184-21-4

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149184-21-4 Structure

Identification	Back Directory
[Name] CGP 54626 HYDROCHLORIDE
[CAS] 149184-21-4
[Synonyms] CGP 54626 [3H]-CGP54626 CGP-54626 HCl CGP 54626 HYDROCHLORIDE TOC CGP 54626 Hydrochloride [S-(R,R)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl)phosphinicacid (S-(R,R))-(3-((1-(3,4-Dichlorophenyl)ethyl)amino)-2-hydroxypropyl)-([3.4-3H]-cyclohexylmethyl)phosphinicacid [S-(R,R)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl)phosphinic acid hydrochloride [S-(R,R)]-[3-[[1-(3,4-DICHLOROPHENYL)ETHYL]AMINO]-2-HYDROXYPROPYL](CYCLOHEXYLMETHYL) PHOSPHINIC ACID HYDROCHLORIDE
[Molecular Formula] C18H27Cl2NO3PT
[MDL Number] MFCD09878291
[MOL File] 149184-21-4.mol
[Molecular Weight] 410.31

Chemical Properties	Back Directory
[storage temp. ] Store at RT
[solubility ] DMF: 0.33 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml; Ethanol: 0.2 mg/ml
[form ] A crystalline solid
[color ] White

Hazard Information	Back Directory
[Description] CGP 54626 is a selective antagonist of the GABA_B receptor with an IC₅₀ value of 4 nM. It can be used to investigate the role of GABA_B receptors in neurological signaling.
[Uses] CGP 54626 (hydrochloride) is a selective antagonist of GABAB receptor with an IC50 value of 4 nM. CGP 54626 (hydrochloride) can be used to investigate the role of GABAB receptors in neurological signaling[1].
[Biological Activity] A potent, selective GABA B receptor antagonist (IC 50 = 4 nM).
[storage] Store at -20°C
[References] [1] Kaupmann K, et al. GABA(B)-receptor subtypes assemble into functional heteromeric complexes. Nature. 1998 Dec 17;396(6712):683-7. DOI:10.1038/25360

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