| Identification | Back Directory | [Name]
DNA, d(P-thio)([2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]rG-G-T-T-A-m5C-A-T-G-A-A-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methox... | [CAS]
1492984-65-2 | [Synonyms]
Inotersen
DNA, d(P-thio)([2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rG-G-T-T-A-m5C-A-T-G-A-A-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rC) |
| Hazard Information | Back Directory | [Uses]
Inotersen is an antisense oligonucleotide that inhibits hepatic production of transthyretin (TTR). | [References]
[1] Benson MD, Waddington-Cruz M, Berk JL, et al. Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis.?N Engl J Med. 2018;379(1):22-31. DOI:10.1056/NEJMoa1716793
[2] Mathew V, Wang AK. Inotersen: new promise for the treatment of hereditary transthyretin amyloidosis.?Drug Des Devel Ther. 2019;13:1515-1525. Published 2019 May 6. DOI:10.2147/DDDT.S162913 |
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