| Identification | Back Directory | [Name]
AACOCF3 | [CAS]
149301-79-1 | [Synonyms]
BPK
ATK
AGMX1
PSCTK1
AATFMK
AACOCF
AACOCF3
Arach-CF3
BTK active human
B cell progenitor kinase
arachidonyltrifluoromethane
Aγglobulinaemia tyrosine kinase
ARACHIDONYL TRIFLUOROMETHYLKETONE
ARACHIDONOYL TRIFLUOROMETHYL KETONE
ARACHIDONIC ACID TRIFLUOROMETHYLKETONE
Bruton agammaglobulinemia tyrosine kinase
1,1,1-TRIFLUORO-6,9,12,15-HENEICOSATETRAEN-2-ONE
1,1,1-TRIFLUORO-6Z,9Z,12Z,15Z-HENEICOSATERAEN-2-ONE
Arachidonyl trifluoromethyl ketone oil, >=97% (NMR)
PDN01791，AACOCF3，Arachidonyl Trifluoromethyl Ketone
1,1,1-TRIFLUORO-6Z,9Z-12Z,15Z-HENEICOSATETRAEN-2-ONE
1,1,1-TRIFLUOROMETHYL-6,9,12,15-HEIEICOSATETRAEN-2-ONE
ARACHIDONYL TRIFLUOROMETHYL KETONE INHIB ITS ANANDAMIDE H
6,9,12,15-Heneicosatetraen-2-one, 1,1,1-trifluoro-, (all-Z)-
6,9,12,15-Heneicosatetraen-2-one, 1,1,1-trifluoro-, (6Z,9Z,12Z,15Z)-
1,1,1-Trifluoromethyl-6,9,12,15-heieicosatetraen-2-one, AACOCF3, Arach-CF3 | [Molecular Formula]
C21H31F3O | [MDL Number]
MFCD00236427 | [MOL File]
149301-79-1.mol | [Molecular Weight]
356.47 |
| Chemical Properties | Back Directory | [Boiling point ]
421.7±45.0 °C(Predicted) | [density ]
0.981±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: >5 mg/mL | [form ]
liquid | [color ]
yellow | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
Arachidonyl trifluoromethyl ketone (AACOCF3) has been used as a anandamide degradation inhibitor to study its effects in primary astrocyte cultures. | [Definition]
ChEBI: A fatty acid derivative that is arachidonic acid in which the OH part of the carboxy group has been replaced by a trifluoromethyl group | [Biological Activity]
Inhibitor of cytosolic (85 kDa) phospholipase A 2 . Also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro . | [Biochem/physiol Actions]
Arachidonyl trifluoromethyl ketone (AACOCF3) plays a role in the inhibition of 12-hydroxyeicosatetraenoic acid (12-HETE) and thromboxane B2 produced by the platelets. | [storage]
-20°C (desiccate) | [References]
[1]. ackermann ej, conde-frieboes k, dennis ea. inhibition of macrophage ca(2+)-independent phospholipase a2 by bromoenol lactone and trifluoromethyl ketones. j biol chem, 1995, 270(1): 445-450.
[2]. riendeau d, guay j, weech pk, et al. arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kda phospholipase a2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. j biol chem, 1994, 269(22): 15619-15624.
[3]. malaviya r, ansell j, hall l, et al. targeting cytosolic phospholipase a2 by arachidonyl trifluoromethyl ketone prevents chronic inflammation in mice. eur j pharmacol, 2006, 539(3): 195-204. |
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