| Identification | Back Directory | [Name]
enalapril sodium salt | [CAS]
149404-21-7 | [Synonyms]
Enalapril sodium
(-)-Enalapril sodium
enalapril sodium salt | [Molecular Formula]
C20H29N2NaO5 | [MOL File]
149404-21-7.mol | [Molecular Weight]
400.45 |
| Hazard Information | Back Directory | [Uses]
Enalapril (MK-421) sodium is an angiotensin-converting enzyme (ACE) inhibitor, can be used for hypertensive diseases research[1][2]. | [in vivo]
Enalapril sodium (intraperitoneal injection, 0.03 mg/kg, once) reduces infarct volume due to middle cerebral artery occlusion and lower or higher doses are ineffective in Male NMRI mice[4]. | Animal Model: | Male NMRI mice 20-40 g[4] | | Dosage: | 0.03 mg/kg | | Administration: | Intraperitoneal injection; once | | Result: | Reduced the area of middle cerebral artery infarction in mice at 0.03 mg/kg. |
| [References]
[1] Serge Sicouri, et al. Antiarrhythmic effects of losartan and enalapril in canine pulmonary vein sleeve preparations. J Cardiovasc Electrophysiol. 2011 Jun;22(6):698-705. DOI:10.1111/j.1540-8167.2010.01972.x
[2] Rokhsareh Meamar, et al. Enalapril protects endothelial cells against induced apoptosis in Alzheimer's disease. J Res Med Sci. 2013 Mar;18(Suppl 1):S1-5. PMID:23961275
[3] Talita A Cunha, et al. Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms. AAPS PharmSciTech. 2013 Sep;14(3):1150-7. DOI:10.1208/s12249-013-0006-6
[4] A Ravati, et al. Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats. Eur J Pharmacol. 1999 May 28;373(1):21-33. DOI:10.1016/s0014-2999(99)00211-3 |
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