| Identification | Back Directory | [Name]
CHRYSOSPLENOLD | [CAS]
14965-20-9 | [Synonyms]
Chrysosplel D
CHRYSOSPLENOLD
7-Methylaxillarin
Quercetagetin 3,6,7-triMethyl ether
5,3',4'-Trihydroxy-3,6,7-trimethoxyflavone
3,6,7-Trimethoxy-3',4',5-trihydroxyflavone
2-(3,4-dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxychromen-4-one
2-(3,4-Dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxy- | [Molecular Formula]
C18H16O8 | [MDL Number]
MFCD01548059 | [MOL File]
14965-20-9.mol | [Molecular Weight]
360.31 |
| Chemical Properties | Back Directory | [Melting point ]
236-238 °C | [Boiling point ]
645.0±55.0 °C(Predicted) | [density ]
1.54±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
6.13±0.40(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities[1][2][3][4]. | [Definition]
ChEBI: 3',4',5-trihydroxy-3,6,7-trimethoxyflavone is a trimethoxyflavone that is the 3,6,7-trimethyl ether derivative of quercetagetin. It has a role as an antineoplastic agent and a metabolite. It is a trihydroxyflavone and a trimethoxyflavone. It is functionally related to a quercetagetin. | [in vivo]
Chrysosplenol D (30 μM; 3 d) inhibits MDA-MB-231 tumor growth on chick chorioallantoic membranes[2].
Chrysosplenol D (0.07-0.28 mmol/kg) protects against LPS-induced systemic inflammatory response syndrome (SIRS) in mice[4].
Chrysosplenol D (1-1.5 μmol/cm2) inhibits croton oil-induced ear edema in mice[4]. | [References]
[1] Habib ES, et, al. Anti-inflammatory effect of methoxyflavonoids from Chiliadenus montanus (Jasonia Montana) growing in Egypt. Nat Prod Res. 2020 Aug 4;1-5. DOI:10.1080/14786419.2020.1802272
[2] Lang SJ, et, al. Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells. Int J Mol Sci. 2020 Jun 8;21(11):4090. DOI:10.3390/ijms21114090
[3] Skaf J, et, al. Improving anti-trypanosomal activity of alkamides isolated from Achillea fragrantissima. Fitoterapia. 2018 Mar;125:191-198. DOI:10.1016/j.fitote.2017.11.001
[4] Li YJ, et, al. Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo. Toxicol Appl Pharmacol. 2015 Aug 1;286(3):151-8. DOI:10.1016/j.taap.2015.04.005 |
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