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Sacubitril Sodium is a potent orally active NEP (enkephalinase) inhibitor with an IC50 of 5 nM. Sacubitril Sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril Sodium is a component of the heart failure drug LCZ696. Sacubitril Sodium is used in heart failure, hypertension and COVID-19 studies. | [in vivo]
In normotensive rats, pretreatment with Sacubitril sodium (3, 10 and 30 mg/kg, PO.) augments ANP-evoked plasma cGMP levels by 2.4, 3.3 and 4.0 fold, respectively (4h AUC compared to vehicle)[1].
Sacubitril sodium (30 and 100 mg/kg, PO) produces a dose-dependent antihypertensive effect in Dahl-SS rats[1]. |
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