| Identification | Back Directory | [Name]
Z-ALA-ALA-ASN-AMC | [CAS]
149697-16-5 | [Synonyms]
Z-AAN-AMC
Z-ALA-ALA-ASN-AMC
Z-ALA-ALA-ASN-MCA
BENZYLOXYCARBONYL-L-ALANYL-L-ALANYL-L-ASPARAGINE 4-METHYLCOUMARYL-7-AMIDE
L-Aspartamide, N-[(phenylmethoxy)carbonyl]-L-alanyl-L-alanyl-N1-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- | [Molecular Formula]
C28H31N5O8 | [MDL Number]
MFCD02684274 | [MOL File]
149697-16-5.mol | [Molecular Weight]
565.57 |
| Chemical Properties | Back Directory | [Boiling point ]
984.1±65.0 °C(Predicted) | [density ]
1.346±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C
| [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
11.14±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC[1]. | [storage]
Store at -20°C | [References]
[1] Stern L, Perry R, Ofek P, Many A, Shabat D, Satchi-Fainaro R. A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain. Bioconjug Chem. 2009;20(3):500-510. DOI:10.1021/bc800448u
[2] James C. Powers, et al. Propenoyl hydrazides. US7482379B2.
[3] Poreba M, et al. Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes. Cell Chem Biol. 2016;23(8):1023-1035. DOI:10.1016/j.chembiol.2016.05.020 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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