| Identification | Back Directory | [Name]
L-N5-(1-IMINOPROPYL) ORNITHINE (HYDROCHLORIDE) | [CAS]
150403-96-6 | [Synonyms]
Methyl-L-NIO Ηydrochloride
FADRJPGCWHNIBW-RGMNGODLSA-N
Methyl-L-NIO (hydrochloride)
L-N5-(1-IMINOPROPYL) ORNITHINE (HYDROCHLORIDE) | [Molecular Formula]
C8H18ClN3O2 | [MDL Number]
MFCD10567090 | [MOL File]
150403-96-6.mol |
| Hazard Information | Back Directory | [Description]
Nitric oxide synthase (NOS) catalyzes the conversion of L-arginine to nitric oxide (NO) and citrulline. Methyl-L-NIO (hydrochloride) is a competitive nitric oxide synthase (NOS) inhibitor that competes with L-arginine for the amino acid binding site. It is a more potent inhibitor of nNOS (Ki = 3.0 μM) than eNOS (Ki = 10.0 μM) or iNOS (Ki = 9.5 μM). | [Uses]
Methyl-L-NIO (compound 2d) hydrochloride is a potential selective inhibitor (IC50: 70 μM) of dimethylarginine dimethylaminohydrolase hDDAH. Methyl-L-NIO also has inhibitory activity against NO synthase. The inhibition rates of Methyl-L-NIO on different isoforms of NO synthase at a concentration of 100 μM are 77% (nNOS), 20% (eNOS), and 72% (iNOS) respectively; the inhibition rates at a concentration of 1 mM are 100% (nNOS), 85% (eNOS), 100% (iNOS)[1]. | [storage]
Store at -20°C | [References]
[1] Kotthaus J, et al. Structure–activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads[J]. Bioorganic & medicinal chemistry, 2008, 16(24): 10205-10209. |
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