| Identification | Back Directory | [Name]
Ethanone, 1-[(3S,3aS)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-3,3a,4,5-tetrahydro-8-methoxy-2H-benz[g]indazol-2-yl]-2-hydroxy- | [CAS]
1504558-72-8 | [Synonyms]
Nec-3a
Ethanone, 1-[(3S,3aS)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-3,3a,4,5-tetrahydro-8-methoxy-2H-benz[g]indazol-2-yl]-2-hydroxy- | [Molecular Formula]
C21 H18 F4 N2 O4 | [MOL File]
1504558-72-8.mol | [Molecular Weight]
438.37 |
| Hazard Information | Back Directory | [Uses]
Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC50: 0.44 μM). Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain[1]. | [IC 50]
RIPK1: 0.44 μM (IC50) | [References]
[1] Xie T, et al. Structural basis of RIP1 inhibition by necrostatins. Structure. 2013 Mar 5;21(3):493-9. DOI:10.1016/j.str.2013.01.016 |
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